Wednesday, 16th February Lorne Infection and Immunity 2022

• Hijacking proteostasis: new strategies for antimalarial drug development - Leann Tilley

• Deep tissue infection by an invasive human fungal pathogen requires novel lipid-based suppression of the IL-17 response - Suzanne Noble
• Coxiella burnetii effector MceF employs the host protein GPX4 to protect mitochondria against oxidative stress-induced cell death pathways - Robson Kriiger Loterio
• TRIM25 and DEAD-box RNA helicase DDX3X cooperate to regulate RIG-I-mediated antiviral immunity - Natalie A Borg
• Bacterial self defence – Haemophilus influenzae S-oxide reductases as determinants of successful host-pathogen interactions - Ulrike Kappler
• Mechanisms of Survival of Latent Toxoplasma - Chris Tonkin

The conference acknowledges the support of:

• Comprehensive mapping of innate and adaptive immune response dynamics across the blood and respiratory tract in COVID-19 - Thomas Ashhurst
• Illuminating intracellular STING trafficking - Katherine R Balka
• Chlamydia pneumoniae infects the brain via olfactory and trigeminal nerves and triggers Alzheimer’s disease pathologies - Ali Delbaz
• A1 limits pathogen-induced macrophage and monocyte cell death and inflammatory responses - Tirta (Mario) Djajawi
• Differential immune detection of Bacteroides fragilis bacteria and their secreted outer membrane vesicles - William Gilmore
• DURABILITY OF B-CELL MEMORY TO SARS-CoV-2 INFECTION AND VACCINATION - Gemma E Hartley
• Proteomics biomarker discovery for the early diagnosis of neonatal sepsis - Julie Hibbert
• Polymicrobial infection interferes pathogen-specific neutrophil responses and impairs bacterial clearance. - Patrick Hien-Neng PHN Kao
• Nonsense-mediated decay is highly divergent in the malaria parasite Plasmodium falciparum - Emma McHugh
• Dimeric IgA as a novel biomarker of acute measles infection - Khayriyyah Mohd Hanafiah

• A human turn of the TAP to more faithfully model herpes simplex virus infection - David Tscharke
• Unravelling the features of T cell Response to a dominant HLA B57-Restricted Gag epitope in HIV⁺ Controllers and non-Controllers - Demetra SM Chatzileontiadou
• Antibody immunity to SARS-CoV-2 by infection and vaccination - Sophie A Valkenburg
• Caspase-8 has dual roles in regulatory T cell homeostasis that balance immunity to infection and inflammatory pathology. - Daniel HD Gray
• Regulation of immunity to infection by emergency cDCpoiesis - Caetano Reis e Sousa

Sciences Bite presented who presented during Session 3 will be available for questions during this session.

• Investigating the immune control of herpesvirus infection in marine molluscs - Jacinta R Agius
• Molecular surveillance of asymptomatic Plasmodium falciparum malaria in high-transmission regions in the context of interventions - Dionne C. Argyropoulos
• New insights into the immunological roles of macrophages adjacent to the rete testis and tunica albuginea - Sneha Biniwale
• Methods of vesicle production and quantification can influence immunological outcomes.  - Natalie Bitto
• Targeting T follicular helper cells to improve immunity to malaria - Michelle Boyle
• Charting elimination in the pandemic: a SARS-CoV-2 serosurvey of blood donors in New Zealand - Lauren H. Carlton
• Inflammatory bowel disease remodels circulating and tissue-resident populations of human Vd1⁺ T cells. - Priyanka PC Chevour
• Benchmarking transcriptional profiles of immune cells online at Stemformatics - Jarny Choi
• Australian Aboriginal children with otitis media produce high avidity serum IgG to potential non-typeable Haemophilus influenzae vaccine antigens at lower titres when compared to non-Aboriginal children - Sharon L Clark
• Developing antimicrobial zinc ion embedded polymers for One Health applications - Bliss A Cunningham
• The sulfonylpiperazine MMV020291 prevents red blood cell invasion through interference with actin-1/profilin dynamics in the malaria parasite Plasmodium falciparum - Madeline Dans
• The good, the bad and the ugly: The functional IgA response in convalescent COVID-19 patients. - Samantha Davis
• Interferon ε as a novel regulator of intestinal homeostasis - Eveline D de Geus
• Developing inhibitors against fungal inositol polyphosphate kinases (IPK) as a novel class of antifungal drug - Desmarini Desmarini
• Functional overlap of different cell death pathways ensures host protection against intracellular bacterial pathogens - Marcel Doerflinger
• Activation of cytotoxic Vγ9Vδ2 T cells during primary Plasmodium falciparum infection - Nicholas Dooley
• Targeted HBeAg seroclearance in a chronic-like HBV mouse model using chimeric bionanoparticles. - Yianni Droungas
• Screening of a panel of FDA-approved drugs to identify CCL17-inhibiting candidates - Mahtab ME Eivazitork
• RIPK1/3 regulates T cell responses in mucosal defence against bacterial gut infection - Vik Ven Eng
• Programming Vγ9Vδ2 T cells for HIV immunotherapies - Kirsty R Field
• Drug screening to uncover novel aspects of Salmonella infection - Jiyao Gan
• Investigating IL-37 in the setting of bronchopulmonary dysplasia (BPD) - Steven Garrick
• DPP9 deficiency: an Inflammasomopathy which can be rescued by lowering NLRP1/IL-1 signaling - Cassandra R Harapas
• Investigating antimicrobial activity by bacterial members of the human gastrointestinal microbiome - Jamia Hemphill
•  Rare catastrophes and evolutionary winners – Human gene variation and inflammatory programmed cell death - Joanne M Hildebrand
• Characterization of a novel Group A Streptococcus virulence factor Spy0433 - Sher Wei How
• The Plasmodium apicoplast is essential for the construction of glycophosphatidylinositol anchors needed for egress and invasion - Long Huynh
• Structural Basis of Coronavirus E protein interactions with human PALS1 PDZ domain - Airah Javorsky
• Identifying novel commensal virulence strategies and their driver during preterm neonatal sepsis - Isabella Anna Joubert
• Non-canonical ubiquitin-mediated regulation of the dendritic cell receptor Clec9A  and the modulation of immune responses - Mireille H Lahoud
• Molecular basis underpinning the citrullinated self-antigen-mediated T cell immunity - Jia Jia Lim
• The transmembrane adaptor SCIMP recruits Syk for TLR activation - Liping Liu
• Molecular insights into the HLA-B35 molecules’ classification associated with HIV control - Christian A Lobos
• Profiling circulating immunoglobulins and cytokines in Acute Rheumatic Fever Patients - Natalie Lorenz
• Regulation of natural killer cell function in Salmonella Typhimurium infection - Timothy R McCulloch
• TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis - Joseph Menassa
• A blunted GPR183/oxysterol axis during dysglycemia results in delayed recruitment of macrophages to the lung during M. tuberculosis infection - Minh Dao NGO
• Modulation of inflammatory cytokine production through cGMP and Interleukin-1 receptor associated kinase-3 (IRAK3) - Trang Hong Nguyen
• Investigating Memory CD8+ T cell Heterogeneity in Tissues and Tumours - Maleika Osman
• Enhanced nitric oxide production by macrophages treated with SPSB-iNOS inhibitors conjugated to cell-penetrating peptides - Arfatur Rahman
• Benchmarking and developing human pluripotent models of macrophage biology - Nadia Rajab
• Investigating the epigenetic and transcriptional regulation of cytokine production by Plasmodium falciparum-exposed monocytes - David Vincent L. Romero
• Probing the molecular basis of curbing TLR4-driven inflammatory responses - Thomas E Schultz
• A bi-specific VHH antibody targeting the CD1d-Natural Killer T cell axis that displays potent anti-tumour immunity. - Adam Shahine
• Novel immunomodulation of the non-classical major histocompatibility complex class I-related (MR1) protein and mucosal associated invariant T (MAIT) cells by human herpesviruses - Barry Slobedman
• 3'-UTR length changes form a novel layer of regulation through non-ISGs in the macrophage response to IFNb  - Sarah Straub
• Purine and carbohydrate availability drive Enterococcus faecalis fitness in wound infections - Casandra Tan
• The impact of hypoxia on Zika virus replication is cell type specific - Brooke N Trowbridge
• Lyn inhibits PI3Kγ activity in TLR activated macrophages. - Neeraj Tuladhar
• The role of STAT5 in CCL17-mediated inflammation - Madelyn Watson
• Salmonella Typhimurium induces cIAP1 degradation to promote death in macrophages - Madeleine A Wemyss
• Anti-viral defences in the male reproductive tract: Expression and localisation of the novel type I interferon epsilon - Rukmali Wijayarathna
• The mechanisms of P. aeruginosa OMV biogenesis may alter their cargo composition and subsequent biological functions. - Lauren Zavan
• Culturing human respiratory bacteria to reveal spatial changes and implications in health and disease  - Sara Di Simone
• LRRC15 suppresses SARS-CoV-2 infection and controls collagen production - Matthew A Waller