Thursday, 17th February Lorne Infection and Immunity 2022

• Analysis of the Dynamics and Composition of Lipid Droplets During Viral Infection - Ebony A Monson
• Bromodomain proteins are essential regulators of gene expression and chromatin in Plasmodium falciparum - Michael F Duffy
• Mitochondrial Shape Shifting in the T Cell Response - Erika Pearce

• Eosinophils in Adipose Tissue Thermogenesis - Kate Quinlan
• Metabolic adaptations in ageing T cells - Kylie Quinn
• Development of a 3D cell culture model to study macrophage activation and metabolism - Katrina J Binger
• CD98 controls the metabolic flexibility of low-density neutrophils mobilized by G-CSF - Katherine Martin
• Deconvoluting host cell phosphorylation pathways during infection with a network-based modelling approach - Jack Adderley

• Targeting host-microbial interactions to develop therapies to prevent and treat otitis media - Lea-Ann Kirkham
• WNT signalling shapes inflammatory responses in patients with sepsis - Johanna K Ljungberg
• The transmembrane TLR adaptor SCIMP is a spatiotemporal Erk1/2 scaffold to drive pro-inflammatory responses in macrophages - Richard M Lucas
• Vδ2⁺Vγ9⁺ T-cells downregulate CCR6 following phosphoantigen-driven in vivo expansion in pigtail macaques (Macaca nemestrina) - Isaac M Barber-Axthelm
• Antifungal resistance – shaping the research agenda - Justin Beardsley

The conference acknowledges the support of:

The conference acknowledges the support of:

The conference acknowledges the support of:

• Mucormycosis in the COVID-19 pandemic era - Ashraf Ibrahim
• Unravelling novel epigenetic mechanisms underpinning SARS-CoV-2 infection and implications for novel epi-therapies - Sudha Rao
• SARS-CoV-2 infection in children does not necessitate establishment of adaptive SARS-CoV-2-specific immunological memory - Louise Rowntree
• ILRUN downregulates ACE2 expression and blocks infection of human cells by SARS-CoV-2 - Aaron M Brice
• SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon - Daniel Harari

• Stromal cell heterogeneity in the lungs supports epithelial cell regeneration - Paris Papagianis
• A new in vitro colon simulating model to examine Candida albicans in the presence of human GI microbiota. - Matthew D Prokop
• Wollamide cyclic hexapeptides synergise with tuberculosis antibiotics to inhibit growth of Mycobacterium tuberculosis - Rachel F Rollo
• Investigating the trans-synaptic transfer mechanism of rabies virus. - Vinod Sundaramoorthy
• STING is a critical sensor in CD4⁺ T cells during malaria that stimulates type 1 IFN production, that in turn, promotes the development of IL-10-producing Th1 (Tr1) cells. - Yulin Wang
• Identification and characterisation of the pH-dependent antifungal saltwater crocodile defensin CpoBD13 - Scott Williams
• Characterising the functional diversity of the gastrointestinal microbiota - Remy B Young
• Single-cycle influenza virus vaccine generates lung CD8^₊ Trm with a diverse TCR repertoire that preclude the emergence of virus escape mutants - Ming Z. M. Zheng

The conference acknowledges the support of:

• Interplay of type I and II IFN for the generation of CD8+ Stem-like memory T cells - JOANNA R GROOM
• Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition - Gautham R Balaji
• Interferon epsilon limits ovarian cancer metastasis via tumour-extrinsic mechanisms - Nicole K Campbell
• CD4 T cells Sans Frontières: Division of labor in the lung - Carolyn King
• Synergistic activity of antibodies in multivalent vaccines - Mariagrazia Pizza

Sciences Bite presented who presented during Session 9 will be available for questions during this session.

• Tryptase regulates the epigenetic modification of core histones in mast cell leukemia cells - Sultan Alanazi
• Restricted translation of antiviral cytokines and transcription factors by SARS-CoV-2.  - Marina R Alexander
• Preterm infants exhibit a reduced pro-inflammatory immune response to RSV - Jeremy Anderson
• Cytomegalovirus infection drives an atypical human Vδ2+ T cell compartment - Daniel Arsovski
• Dissecting the role of programmed cell death and inflammation in SARS-CoV-2 infection in vivo  - Stefanie M Bader
• Programmable macrophages understanding the role of nrg1 and macrophage plasticity through synthetic biology - Miguel A Berrocal-Rubio
• Pathophysiological changes in a large animal model of COPD - Rob Bischof
• Tissue-specific contributions of WNT production and signalling to cytokine and chemokine responses during E. coli infection - Rhiannon A Bolton
• Apicoplast derived metabolites are essential for the biosynthesis of glycophosphatidylinositol anchors and egress of asexual stage Plasmodium falciparum. - Michaela Bulloch
• Long-read RNA sequencing identifies polyadenylation elongation and differential transcript usage of host transcripts during SARS-CoV-2 in vitro infection - Jessie J-Y Chang
• Inhaled pirfenidone reduces transforming growth factor-beta-enhanced lung viral infection and inflammation as effectively as oral pirfenidone - Julia G Chitty
• Specific gut microbiota-epithelial cell interactions induces the unfolded protein response and ER stress pathways - Michelle Chonwerawong
• Whole-body analysis of tissue-resident immune cells - Allison Clatch
• Novel fluorescent TNF reporter systems for characterisation of TNF expression - Destiny Dalseno
• PKR is a sensor of proteotoxic stress via accumulation of cytoplasmic IL-24 - Sophia Davidson
• Uncovering resident macrophages in the mammary gland by 3D and intravital imaging - Caleb A Dawson
• The efficacy and safety of pinocembrin in a sheep model of bleomycin-induced pulmonary fibrosis - Habtamu B Derseh
• The calcineurin and TOR signaling pathways are critical for mitigating stress caused by phosphate overload in invasive fungal pathogens - Bethany Bowring
• Rab6b localises to the Golgi complex in murine macrophages and promotes TNF release in response to mycobacterial infection - Leslie C Domínguez Cadena
• Rapid multiplex PCR to detect and characterise polymicrobial sepsis - Mariam Doualeh
• HCV infection induces prolonged inflammation and elevated chronic disease risk biomarkers even after curative direct-acting antiviral treatment - Salimeh Ebrahimnezhaddarzi
• An integrated transcriptional atlas of human dendritic cells - Zahra Elahi
• Molecular mechanisms of apoptosis induction during Salmonella Typhimurium infection - Sven Engel
• Circulating microRNA biomarkers enable accurate identification of COVID-19 patients - Ryan Farr
• Rabies against the machine: using artificial intelligence to find cellular and exosomal microRNA signatures of lyssavirus infection in a human stem-cell derived neural culture - Ryan Farr
• Exploring TRIM proteins as targets for broad spectrum antivirals - Rubaiyea Farrukee
• The GPR183/oxysterol axis controls macrophage infiltration and inflammation in the lung during influenza infection and SARS-CoV-2 infection - Cheng Xiang Foo
• High frequency human MLKL mutation causes innate immune response defects and hematopoietic dysfunction in CRISPR-cas9 generated mouse model. - Sarah E Garnish
• CD8⁺ T cell cross-reactivity towards conserved influenza A and B epitopes - Emma Grant
• The broccoli-derived antioxidant sulforaphane changes the growth of bacteria within the gastrointestinal microbiota. - Emily L Gulliver
• Immunodominance in malarial antibody responses - Julianne L Hamelink
• The naturally derived cytokine peptide LAT8881 limits respiratory virus replication and severe disease - Christopher M Harpur
• Whole-genome CRISPR/Cas9 screen to identify host factors playing a role in Plasmodium falciparum cell traversal     - Eva Hesping
• Loss of β-ketoacyl acyl carrier protein synthase III sensitise multidrug-resistant Escherichia coli to previously ineffective antibiotics  - Yaoqin Hong
• Characterisation of a novel non-canonical interferon pathway in macrophages - Stephanie Huang
• Immuno-epigenomic analysis identifies attenuated interferon responses in naïve CD4 T cells of adolescents with peanut and multi-food allergy - Samira Imran
• Pseudomonas aeruginosa releases outer membrane vesicles containing plasmid DNA that can be transferred to recipient bacteria. - Ella L Johnston
• Identification of SARS-CoV-2 induced senescence reveals a new therapeutic target for COVID-19 - Stephanie J Keating
• Lipid droplets act as platforms for innate immune signalling proteins - Jay Laws
• Identifying the mechanisms of action of novel invasion-blocking compounds in Plasmodium falciparum - Dawson Ling
• Infection-induced WNT responses in macrophages are regulated by innate immune receptor activation - Johanna Ljungberg
• Screening the MMV Malaria Box for inhibitors of Plasmodium falciparum protein export - Oliver Looker
• Transcriptional and epigenetic regulation of CCL17 and CCL22 by GM-CSF and IL4 - Tanya Lupancu
• Determining the effect of HBV splice variant 9 (Sp9) on wildtype HBV replication - Laura McCoullough
• The Persistence of Neutralising Antibodies up to 11 months after SARS-CoV-2 Infection in the Southern Region of New Zealand   - Reuben McGregor
• T follicular helper cell responses during uncomplicated falciparum and vivax malaria - Mayimuna Nalubega
• Spike specific T cell mediated immunity in vaccinated and COVID-19 recovered individuals - Andrea Nguyen
• Single-cell analysis of αβ versus γδ T cell development - Seungyoul SO Oh
• Antibody profiles 6 years following reduced-dose quadrivalent HPV vaccine schedules in adolescent Fijian girls - Chau Quang
• Decoding the Immune Response: Next Generation Sequencing of the Immune Repertoire - Selva Kumari Ramasubramanian
• Novel immunotherapeutic strategies for bronchopulmonary dysplasia - Ina Rudloff
• Development of a high throughput ex-vivo screening assay for peptide-based T cell cancer vaccines - Bansari Shah
• Role of PHIST protein in knob formation - Mohini A Shibu
• A tree-based software for high-resolution analysis of metagenomic samples - Sean Solari
• Limited recognition of highly conserved regions of SARS-CoV-2 - Srividhya Swaminathan
• Assessment of IgG3 as a serological exposure marker for Plasmodium vivax malaria in moderate endemic areas  - Yanie Tayipto
• Identifying inhibitors of plasmid conjugation to reduce the spread of antibiotic resistance genes - Aurelie Tsee
• Investigating the molecular mechanisms of STING responses - Rajan Venkatraman
• Increased breadth of Group A Streptococcus antibody responses in children with acute rheumatic fever compared to precursor pharyngitis and skin infections - Alana L Whitcombe
• MAIT cells expand in the absence of NKT and γδT cells - Calvin Xu
• High prevalence of Capsid-antibody-complexes (CACs) in sera of chronic hepatitis B patients and its association with chronic liver disease - Xiaonan Zhang